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KMID : 0369819910210010001
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Jorunal of Korean Pharmaceutical Sciences
1991 Volume.21 No. 1 p.1 ~ p.10
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Controlled Release Properties of Ketoprofen from Methacrylate Polymer Gels
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한건/Han K
박정숙/김낙서/정연복/차철희/Park JS/Kim NS/Chung YB/Cha CH
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Abstract
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Hydrogels containing ketoprofen were prepared by adding NaOH or $Ca(OH)_2$ 수식 이미지 solution to Eudragit L, S and Eudispert hv at various concentration. And xerogels were prepared by drying hydrogels. On the other hand, organogels containing ketoprofen were prepared by mixing Eudragit L or S and propylene glycol. Effects of polymer content and base on drug release were investigated using KP V dissolution method. The release rate of ketoprofen from Eudragit L & S hydrogel decreased with increasing in polymer content. And the drug release rate from cal. hydroxide based gels were more decreased than that from sod. hydroxide based gels. At pH 7.2 dissolution medium, e release of ketoprofen from Edispert hv hydrogel followed apparent zero order kinetics. The release of ketoprofen from xerogel involved in simultaneous absorption of water and desorption of ketoprofen via a pH-dependant swelling controlled mechanism. The release of ketoprofen from Eudragit S organogels followed apparent zero order kinetics, providing strong evidence for a surface erosion mechanism.
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KEYWORD
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